SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells
Identifieur interne : 000448 ( Main/Exploration ); précédent : 000447; suivant : 000449SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells
Auteurs : Jun-Man Hong ; Jin-Hee Kim [Corée du Sud] ; Hyemin Kim [Corée du Sud] ; Wang Jae Lee ; Young-Il HwangSource :
- Molecules [ 1420-3049 ] ; 2019.
Abstract
SB365, a saponin D extracted from the roots of
Url:
DOI: 10.3390/molecules24183230
PubMed: 31491945
PubMed Central: 6766801
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000720
- to stream Pmc, to step Curation: 000720
- to stream Pmc, to step Checkpoint: 000404
- to stream Ncbi, to step Merge: 000A01
- to stream Ncbi, to step Curation: 000A01
- to stream Ncbi, to step Checkpoint: 000A01
- to stream Main, to step Merge: 000448
- to stream Main, to step Curation: 000448
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SB365, <italic>Pulsatilla</italic> Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells</title><author><name sortKey="Hong, Jun Man" sort="Hong, Jun Man" uniqKey="Hong J" first="Jun-Man" last="Hong">Jun-Man Hong</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin-Hee" last="Kim">Jin-Hee Kim</name><affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-03230">Department of Biomedical Laboratory Science, Cheongju University, Cheongju 28503, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Cheongju University, Cheongju 28503</wicri:regionArea><wicri:noRegion>Cheongju 28503</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hyemin" sort="Kim, Hyemin" uniqKey="Kim H" first="Hyemin" last="Kim">Hyemin Kim</name><affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-03230">Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Wang Jae" sort="Lee, Wang Jae" uniqKey="Lee W" first="Wang Jae" last="Lee">Wang Jae Lee</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author><author><name sortKey="Hwang, Young Il" sort="Hwang, Young Il" uniqKey="Hwang Y" first="Young-Il" last="Hwang">Young-Il Hwang</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31491945</idno><idno type="pmc">6766801</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766801</idno><idno type="RBID">PMC:6766801</idno><idno type="doi">10.3390/molecules24183230</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000720</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000720</idno><idno type="wicri:Area/Pmc/Curation">000720</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000720</idno><idno type="wicri:Area/Pmc/Checkpoint">000404</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000404</idno><idno type="wicri:Area/Ncbi/Merge">000A01</idno><idno type="wicri:Area/Ncbi/Curation">000A01</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A01</idno><idno type="wicri:Area/Main/Merge">000448</idno><idno type="wicri:Area/Main/Curation">000448</idno><idno type="wicri:Area/Main/Exploration">000448</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SB365, <italic>Pulsatilla</italic> Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells</title><author><name sortKey="Hong, Jun Man" sort="Hong, Jun Man" uniqKey="Hong J" first="Jun-Man" last="Hong">Jun-Man Hong</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin-Hee" last="Kim">Jin-Hee Kim</name><affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-03230">Department of Biomedical Laboratory Science, Cheongju University, Cheongju 28503, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Cheongju University, Cheongju 28503</wicri:regionArea><wicri:noRegion>Cheongju 28503</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hyemin" sort="Kim, Hyemin" uniqKey="Kim H" first="Hyemin" last="Kim">Hyemin Kim</name><affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-03230">Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Wang Jae" sort="Lee, Wang Jae" uniqKey="Lee W" first="Wang Jae" last="Lee">Wang Jae Lee</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author><author><name sortKey="Hwang, Young Il" sort="Hwang, Young Il" uniqKey="Hwang Y" first="Young-Il" last="Hwang">Young-Il Hwang</name><affiliation><nlm:aff id="af1-molecules-24-03230">Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul 03080, Korea (J.-M.H.) (W.J.L.)</nlm:aff><wicri:noCountry code="subfield">Korea (J.-M.H.) (W.J.L.)</wicri:noCountry></affiliation></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>SB365, a saponin D extracted from the roots of <italic>Pulsatilla koreana</italic>, has been reported to show cytotoxicity in several cancer cell lines. We investigated the effects of SB365 on U87-MG and T98G glioblastoma multiforme (GBM) cells, and its efficacy in combination with temozolomide for treating GBM. SB365 exerted a cytotoxic effect on GBM cells not by inducing apoptosis, as in other cancer cell lines, but by triggering caspase-independent cell death. Inhibition of autophagic flux and neutralization of the lysosomal pH occurred rapidly after application of SB365, followed by deterioration of mitochondrial membrane potential. A cathepsin B inhibitor and <italic>N</italic>-acetyl cysteine, an antioxidant, partially recovered cell death induced by SB365. SB365 in combination with temozolomide exerted an additive cytotoxic effect in vitro and in vivo. In conclusion, SB365 inhibits autophagic flux and induces caspase-independent cell death in GBM cells in a manner involving cathepsin B and mainly reactive oxygen species, and its use in combination with temozolomide shows promise for the treatment of GBM.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morgan, E R" uniqKey="Morgan E">E.R. Morgan</name></author><author><name sortKey="Norman, A" uniqKey="Norman A">A. Norman</name></author><author><name sortKey="Laing, K" uniqKey="Laing K">K. Laing</name></author><author><name sortKey="Seal, M D" uniqKey="Seal M">M.D. Seal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paolillo, M" uniqKey="Paolillo M">M. Paolillo</name></author><author><name sortKey="Boselli, C" uniqKey="Boselli C">C. Boselli</name></author><author><name sortKey="Schinelli, S" uniqKey="Schinelli S">S. Schinelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Yang, G" uniqKey="Yang G">G. Yang</name></author><author><name sortKey="Zhang, Y Y" uniqKey="Zhang Y">Y.Y. Zhang</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name></author><author><name sortKey="Dong, L H" uniqKey="Dong L">L.H. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stupp, R" uniqKey="Stupp R">R. Stupp</name></author><author><name sortKey="Dietrich, P Y" uniqKey="Dietrich P">P.Y. Dietrich</name></author><author><name sortKey="Kraljevic, S O" uniqKey="Kraljevic S">S.O. Kraljevic</name></author><author><name sortKey="Pica, A" uniqKey="Pica A">A. Pica</name></author><author><name sortKey="Maillard, I" uniqKey="Maillard I">I. Maillard</name></author><author><name sortKey="Maeder, P" uniqKey="Maeder P">P. Maeder</name></author><author><name sortKey="Meuli, R" uniqKey="Meuli R">R. Meuli</name></author><author><name sortKey="Janzer, R" uniqKey="Janzer R">R. Janzer</name></author><author><name sortKey="Pizzolato, G" uniqKey="Pizzolato G">G. Pizzolato</name></author><author><name sortKey="Miralbell, R" uniqKey="Miralbell R">R. Miralbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Tri, S" uniqKey="D Tri S">S. D’Atri</name></author><author><name sortKey="Tentori, L" uniqKey="Tentori L">L. Tentori</name></author><author><name sortKey="Lacal, P M" uniqKey="Lacal P">P.M. Lacal</name></author><author><name sortKey="Graziani, G" uniqKey="Graziani G">G. Graziani</name></author><author><name sortKey="Pagani, E" uniqKey="Pagani E">E. Pagani</name></author><author><name sortKey="Benincasa, E" uniqKey="Benincasa E">E. Benincasa</name></author><author><name sortKey="Zambruno, G" uniqKey="Zambruno G">G. Zambruno</name></author><author><name sortKey="Bonmassar, E" uniqKey="Bonmassar E">E. Bonmassar</name></author><author><name sortKey="Jiricny, J" uniqKey="Jiricny J">J. Jiricny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostermann, S" uniqKey="Ostermann S">S. Ostermann</name></author><author><name sortKey="Csajka, C" uniqKey="Csajka C">C. Csajka</name></author><author><name sortKey="Buclin, T" uniqKey="Buclin T">T. Buclin</name></author><author><name sortKey="Leyvraz, S" uniqKey="Leyvraz S">S. Leyvraz</name></author><author><name sortKey="Lejeune, F" uniqKey="Lejeune F">F. Lejeune</name></author><author><name sortKey="Decosterd, L A" uniqKey="Decosterd L">L.A. Decosterd</name></author><author><name sortKey="Stupp, R" uniqKey="Stupp R">R. Stupp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bocangel, D B" uniqKey="Bocangel D">D.B. Bocangel</name></author><author><name sortKey="Finkelstein, S" uniqKey="Finkelstein S">S. Finkelstein</name></author><author><name sortKey="Schold, S C" uniqKey="Schold S">S.C. Schold</name></author><author><name sortKey="Bhakat, K K" uniqKey="Bhakat K">K.K. Bhakat</name></author><author><name sortKey="Mitra, S" uniqKey="Mitra S">S. Mitra</name></author><author><name sortKey="Kokkinakis, D M" uniqKey="Kokkinakis D">D.M. Kokkinakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, M R" uniqKey="Gilbert M">M.R. Gilbert</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Aldape, K D" uniqKey="Aldape K">K.D. Aldape</name></author><author><name sortKey="Stupp, R" uniqKey="Stupp R">R. Stupp</name></author><author><name sortKey="Hegi, M E" uniqKey="Hegi M">M.E. Hegi</name></author><author><name sortKey="Jaeckle, K A" uniqKey="Jaeckle K">K.A. Jaeckle</name></author><author><name sortKey="Armstrong, T S" uniqKey="Armstrong T">T.S. Armstrong</name></author><author><name sortKey="Wefel, J S" uniqKey="Wefel J">J.S. Wefel</name></author><author><name sortKey="Won, M" uniqKey="Won M">M. Won</name></author><author><name sortKey="Blumenthal, D T" uniqKey="Blumenthal D">D.T. Blumenthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bozic, I" uniqKey="Bozic I">I. Bozic</name></author><author><name sortKey="Reiter, J G" uniqKey="Reiter J">J.G. Reiter</name></author><author><name sortKey="Allen, B" uniqKey="Allen B">B. Allen</name></author><author><name sortKey="Antal, T" uniqKey="Antal T">T. Antal</name></author><author><name sortKey="Chatterjee, K" uniqKey="Chatterjee K">K. Chatterjee</name></author><author><name sortKey="Shah, P" uniqKey="Shah P">P. Shah</name></author><author><name sortKey="Moon, Y S" uniqKey="Moon Y">Y.S. Moon</name></author><author><name sortKey="Yaqubie, A" uniqKey="Yaqubie A">A. Yaqubie</name></author><author><name sortKey="Kelly, N" uniqKey="Kelly N">N. Kelly</name></author><author><name sortKey="Le, D T" uniqKey="Le D">D.T. Le</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenfeld, M R" uniqKey="Rosenfeld M">M.R. Rosenfeld</name></author><author><name sortKey="Ye, X B" uniqKey="Ye X">X.B. Ye</name></author><author><name sortKey="Supko, J G" uniqKey="Supko J">J.G. Supko</name></author><author><name sortKey="Desideri, S" uniqKey="Desideri S">S. Desideri</name></author><author><name sortKey="Grossman, S A" uniqKey="Grossman S">S.A. Grossman</name></author><author><name sortKey="Brem, S" uniqKey="Brem S">S. Brem</name></author><author><name sortKey="Mikkelson, T" uniqKey="Mikkelson T">T. Mikkelson</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Chang, Y Y C" uniqKey="Chang Y">Y.Y.C. Chang</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Bang, S C" uniqKey="Bang S">S.-C. Bang</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J.-H. Lee</name></author><author><name sortKey="Ahn, B Z" uniqKey="Ahn B">B.-Z. Ahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bang, S C" uniqKey="Bang S">S.C. Bang</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J.H. Lee</name></author><author><name sortKey="Song, G Y" uniqKey="Song G">G.Y. Song</name></author><author><name sortKey="Kim, D H" uniqKey="Kim D">D.H. Kim</name></author><author><name sortKey="Yoon, M Y" uniqKey="Yoon M">M.Y. Yoon</name></author><author><name sortKey="Ahn, B Z" uniqKey="Ahn B">B.Z. Ahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S W" uniqKey="Hong S">S.W. Hong</name></author><author><name sortKey="Jung, K H" uniqKey="Jung K">K.H. Jung</name></author><author><name sortKey="Lee, H S" uniqKey="Lee H">H.S. Lee</name></author><author><name sortKey="Choi, M J" uniqKey="Choi M">M.J. Choi</name></author><author><name sortKey="Son, M K" uniqKey="Son M">M.K. Son</name></author><author><name sortKey="Zheng, H M" uniqKey="Zheng H">H.M. Zheng</name></author><author><name sortKey="Hong, S S" uniqKey="Hong S">S.S. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S W" uniqKey="Hong S">S.W. Hong</name></author><author><name sortKey="Jung, K H" uniqKey="Jung K">K.H. Jung</name></author><author><name sortKey="Lee, H S" uniqKey="Lee H">H.S. Lee</name></author><author><name sortKey="Son, M K" uniqKey="Son M">M.K. Son</name></author><author><name sortKey="Yan, H H" uniqKey="Yan H">H.H. Yan</name></author><author><name sortKey="Kang, N S" uniqKey="Kang N">N.S. Kang</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name></author><author><name sortKey="Hong, S S" uniqKey="Hong S">S.S. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Son, M K" uniqKey="Son M">M.K. Son</name></author><author><name sortKey="Jung, K H" uniqKey="Jung K">K.H. Jung</name></author><author><name sortKey="Hong, S W" uniqKey="Hong S">S.W. Hong</name></author><author><name sortKey="Lee, H S" uniqKey="Lee H">H.S. Lee</name></author><author><name sortKey="Zheng, H M" uniqKey="Zheng H">H.M. Zheng</name></author><author><name sortKey="Choi, M J" uniqKey="Choi M">M.J. Choi</name></author><author><name sortKey="Seo, J H" uniqKey="Seo J">J.H. Seo</name></author><author><name sortKey="Suh, J K" uniqKey="Suh J">J.K. Suh</name></author><author><name sortKey="Hong, S S" uniqKey="Hong S">S.S. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Son, M K" uniqKey="Son M">M.K. Son</name></author><author><name sortKey="Jung, K H" uniqKey="Jung K">K.H. Jung</name></author><author><name sortKey="Lee, H S" uniqKey="Lee H">H.S. Lee</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name></author><author><name sortKey="Kim, S J" uniqKey="Kim S">S.J. Kim</name></author><author><name sortKey="Yan, H H" uniqKey="Yan H">H.H. Yan</name></author><author><name sortKey="Ryu, Y L" uniqKey="Ryu Y">Y.L. Ryu</name></author><author><name sortKey="Hong, S S" uniqKey="Hong S">S.S. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moon, K S" uniqKey="Moon K">K.S. Moon</name></author><author><name sortKey="Ji, J Y" uniqKey="Ji J">J.Y. Ji</name></author><author><name sortKey="Cho, Y J" uniqKey="Cho Y">Y.J. Cho</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J.H. Lee</name></author><author><name sortKey="Choi, M S" uniqKey="Choi M">M.S. Choi</name></author><author><name sortKey="Kim, E E" uniqKey="Kim E">E.E. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, W J" uniqKey="Jang W">W.J. Jang</name></author><author><name sortKey="Park, B" uniqKey="Park B">B. Park</name></author><author><name sortKey="Jeong, G S" uniqKey="Jeong G">G.S. Jeong</name></author><author><name sortKey="Hong, S S" uniqKey="Hong S">S.S. Hong</name></author><author><name sortKey="Jeong, C H" uniqKey="Jeong C">C.H. Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y L" uniqKey="Zhang Y">Y.L. Zhang</name></author><author><name sortKey="Bao, J L" uniqKey="Bao J">J.L. Bao</name></author><author><name sortKey="Wang, K" uniqKey="Wang K">K. Wang</name></author><author><name sortKey="Jia, X J" uniqKey="Jia X">X.J. Jia</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Huang, B R" uniqKey="Huang B">B.R. Huang</name></author><author><name sortKey="Chen, M W" uniqKey="Chen M">M.W. Chen</name></author><author><name sortKey="Wan, J B" uniqKey="Wan J">J.B. Wan</name></author><author><name sortKey="Su, H X" uniqKey="Su H">H.X. Su</name></author><author><name sortKey="Wang, Y T" uniqKey="Wang Y">Y.T. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, A" uniqKey="Gupta A">A. Gupta</name></author><author><name sortKey="Dwivedi, T" uniqKey="Dwivedi T">T. Dwivedi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Y" uniqKey="Xie Y">Y. Xie</name></author><author><name sortKey="Bergstrom, T" uniqKey="Bergstrom T">T. Bergstrom</name></author><author><name sortKey="Jiang, Y W" uniqKey="Jiang Y">Y.W. Jiang</name></author><author><name sortKey="Johansson, P" uniqKey="Johansson P">P. Johansson</name></author><author><name sortKey="Marinescu, V D" uniqKey="Marinescu V">V.D. Marinescu</name></author><author><name sortKey="Lindberg, N" uniqKey="Lindberg N">N. Lindberg</name></author><author><name sortKey="Segerman, A" uniqKey="Segerman A">A. Segerman</name></author><author><name sortKey="Wicher, G" uniqKey="Wicher G">G. Wicher</name></author><author><name sortKey="Niklasson, M" uniqKey="Niklasson M">M. Niklasson</name></author><author><name sortKey="Baskaran, S" uniqKey="Baskaran S">S. Baskaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kokkinakis, D M" uniqKey="Kokkinakis D">D.M. Kokkinakis</name></author><author><name sortKey="Bocangel, D B" uniqKey="Bocangel D">D.B. Bocangel</name></author><author><name sortKey="Schold, S C" uniqKey="Schold S">S.C. Schold</name></author><author><name sortKey="Moschel, R C" uniqKey="Moschel R">R.C. Moschel</name></author><author><name sortKey="Pegg, A E" uniqKey="Pegg A">A.E. Pegg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hegi, M E" uniqKey="Hegi M">M.E. Hegi</name></author><author><name sortKey="Diserens, A" uniqKey="Diserens A">A. Diserens</name></author><author><name sortKey="Gorlia, T" uniqKey="Gorlia T">T. Gorlia</name></author><author><name sortKey="Hamou, M" uniqKey="Hamou M">M. Hamou</name></author><author><name sortKey="De Tribolet, N" uniqKey="De Tribolet N">N. de Tribolet</name></author><author><name sortKey="Weller, M" uniqKey="Weller M">M. Weller</name></author><author><name sortKey="Kros, J M" uniqKey="Kros J">J.M. Kros</name></author><author><name sortKey="Hainfellner, J A" uniqKey="Hainfellner J">J.A. Hainfellner</name></author><author><name sortKey="Mason, W" uniqKey="Mason W">W. Mason</name></author><author><name sortKey="Mariani, L" uniqKey="Mariani L">L. Mariani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vermes, I" uniqKey="Vermes I">I. Vermes</name></author><author><name sortKey="Haanen, C" uniqKey="Haanen C">C. Haanen</name></author><author><name sortKey="Reutelingsperger, C" uniqKey="Reutelingsperger C">C. Reutelingsperger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, K H" uniqKey="Khan K">K.H. Khan</name></author><author><name sortKey="Blanco Codesido, M" uniqKey="Blanco Codesido M">M. Blanco-Codesido</name></author><author><name sortKey="Molife, L R" uniqKey="Molife L">L.R. Molife</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carloni, S" uniqKey="Carloni S">S. Carloni</name></author><author><name sortKey="Buonocore, G" uniqKey="Buonocore G">G. Buonocore</name></author><author><name sortKey="Balduini, W" uniqKey="Balduini W">W. Balduini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pankiv, S" uniqKey="Pankiv S">S. Pankiv</name></author><author><name sortKey="Clausen, T H" uniqKey="Clausen T">T.H. Clausen</name></author><author><name sortKey="Lamark, T" uniqKey="Lamark T">T. Lamark</name></author><author><name sortKey="Brech, A" uniqKey="Brech A">A. Brech</name></author><author><name sortKey="Bruun, J A" uniqKey="Bruun J">J.A. Bruun</name></author><author><name sortKey="Outzen, H" uniqKey="Outzen H">H. Outzen</name></author><author><name sortKey="Overvatn, A" uniqKey="Overvatn A">A. Overvatn</name></author><author><name sortKey="Bjorkoy, G" uniqKey="Bjorkoy G">G. Bjorkoy</name></author><author><name sortKey="Johansen, T" uniqKey="Johansen T">T. Johansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, P" uniqKey="Jiang P">P. Jiang</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vallecillo Hernandez, J" uniqKey="Vallecillo Hernandez J">J. Vallecillo-Hernández</name></author><author><name sortKey="Barrachina, M D" uniqKey="Barrachina M">M.D. Barrachina</name></author><author><name sortKey="Ortiz Masia, D" uniqKey="Ortiz Masia D">D. Ortiz-Masiá</name></author><author><name sortKey="Coll, S" uniqKey="Coll S">S. Coll</name></author><author><name sortKey="Esplugues, J V" uniqKey="Esplugues J">J.V. Esplugues</name></author><author><name sortKey="Calatayud, S" uniqKey="Calatayud S">S. Calatayud</name></author><author><name sortKey="Hernandez, C" uniqKey="Hernandez C">C. Hernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boya, P" uniqKey="Boya P">P. Boya</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Racoma, I O" uniqKey="Racoma I">I.O. Racoma</name></author><author><name sortKey="Meisen, W H" uniqKey="Meisen W">W.H. Meisen</name></author><author><name sortKey="Wang, Q E" uniqKey="Wang Q">Q.E. Wang</name></author><author><name sortKey="Kaur, B" uniqKey="Kaur B">B. Kaur</name></author><author><name sortKey="Wani, A A" uniqKey="Wani A">A.A. Wani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noguchi, S" uniqKey="Noguchi S">S. Noguchi</name></author><author><name sortKey="Shibutani, S" uniqKey="Shibutani S">S. Shibutani</name></author><author><name sortKey="Fukushima, K" uniqKey="Fukushima K">K. Fukushima</name></author><author><name sortKey="Mori, T" uniqKey="Mori T">T. Mori</name></author><author><name sortKey="Igase, M" uniqKey="Igase M">M. Igase</name></author><author><name sortKey="Mizuno, T" uniqKey="Mizuno T">T. Mizuno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geng, Y" uniqKey="Geng Y">Y. Geng</name></author><author><name sortKey="Kohli, L" uniqKey="Kohli L">L. Kohli</name></author><author><name sortKey="Klocke, B J" uniqKey="Klocke B">B.J. Klocke</name></author><author><name sortKey="Roth, K A" uniqKey="Roth K">K.A. Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, K" uniqKey="Bray K">K. Bray</name></author><author><name sortKey="Mathew, R" uniqKey="Mathew R">R. Mathew</name></author><author><name sortKey="Lau, A" uniqKey="Lau A">A. Lau</name></author><author><name sortKey="Kamphorst, J J" uniqKey="Kamphorst J">J.J. Kamphorst</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J. Fan</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Ghavami, A" uniqKey="Ghavami A">A. Ghavami</name></author><author><name sortKey="Stein, M" uniqKey="Stein M">M. Stein</name></author><author><name sortKey="Dipaola, R S" uniqKey="Dipaola R">R.S. DiPaola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klose, J" uniqKey="Klose J">J. Klose</name></author><author><name sortKey="Stankov, M V" uniqKey="Stankov M">M.V. Stankov</name></author><author><name sortKey="Kleine, M" uniqKey="Kleine M">M. Kleine</name></author><author><name sortKey="Ramackers, W" uniqKey="Ramackers W">W. Ramackers</name></author><author><name sortKey="Panayotova Dimitrova, D" uniqKey="Panayotova Dimitrova D">D. Panayotova-Dimitrova</name></author><author><name sortKey="Jager, M D" uniqKey="Jager M">M.D. Jager</name></author><author><name sortKey="Klempnauer, J" uniqKey="Klempnauer J">J. Klempnauer</name></author><author><name sortKey="Winkler, M" uniqKey="Winkler M">M. Winkler</name></author><author><name sortKey="Bektas, H" uniqKey="Bektas H">H. Bektas</name></author><author><name sortKey="Behrens, G M N" uniqKey="Behrens G">G.M.N. Behrens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N Y" uniqKey="Li N">N.Y. Li</name></author><author><name sortKey="Oquendo, E" uniqKey="Oquendo E">E. Oquendo</name></author><author><name sortKey="Capaldi, R A" uniqKey="Capaldi R">R.A. Capaldi</name></author><author><name sortKey="Robinson, J P" uniqKey="Robinson J">J.P. Robinson</name></author><author><name sortKey="He, Y D D" uniqKey="He Y">Y.D.D. He</name></author><author><name sortKey="Hamadeh, H K" uniqKey="Hamadeh H">H.K. Hamadeh</name></author><author><name sortKey="Afshari, C A" uniqKey="Afshari C">C.A. Afshari</name></author><author><name sortKey="Lightfoot Dunn, R" uniqKey="Lightfoot Dunn R">R. Lightfoot-Dunn</name></author><author><name sortKey="Narayanan, P K" uniqKey="Narayanan P">P.K. Narayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J H" uniqKey="Song J">J.H. Song</name></author><author><name sortKey="Song, D K" uniqKey="Song D">D.K. Song</name></author><author><name sortKey="Pyrzynska, B" uniqKey="Pyrzynska B">B. Pyrzynska</name></author><author><name sortKey="Petruk, K C" uniqKey="Petruk K">K.C. Petruk</name></author><author><name sortKey="Van Meir, E G" uniqKey="Van Meir E">E.G. Van Meir</name></author><author><name sortKey="Hao, C H" uniqKey="Hao C">C.H. Hao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, K A" uniqKey="Kang K">K.A. Kang</name></author><author><name sortKey="Piao, M J" uniqKey="Piao M">M.J. Piao</name></author><author><name sortKey="Hyun, Y J" uniqKey="Hyun Y">Y.J. Hyun</name></author><author><name sortKey="Zhen, A X" uniqKey="Zhen A">A.X. Zhen</name></author><author><name sortKey="Cho, S J" uniqKey="Cho S">S.J. Cho</name></author><author><name sortKey="Ahn, M J" uniqKey="Ahn M">M.J. Ahn</name></author><author><name sortKey="Yi, J M" uniqKey="Yi J">J.M. Yi</name></author><author><name sortKey="Hyun, J W" uniqKey="Hyun J">J.W. Hyun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, C H" uniqKey="Jung C">C.H. Jung</name></author><author><name sortKey="Jun, C B" uniqKey="Jun C">C.B. Jun</name></author><author><name sortKey="Ro, S H" uniqKey="Ro S">S.-H. Ro</name></author><author><name sortKey="Kim, Y M" uniqKey="Kim Y">Y.-M. Kim</name></author><author><name sortKey="Otto, N M" uniqKey="Otto N">N.M. Otto</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J. Cao</name></author><author><name sortKey="Kundu, M" uniqKey="Kundu M">M. Kundu</name></author><author><name sortKey="Kim, D H" uniqKey="Kim D">D.-H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J. Gu</name></author><author><name sortKey="Hu, W" uniqKey="Hu W">W. Hu</name></author><author><name sortKey="Song, Z P" uniqKey="Song Z">Z.P. Song</name></author><author><name sortKey="Chen, Y G" uniqKey="Chen Y">Y.G. Chen</name></author><author><name sortKey="Zhang, D D" uniqKey="Zhang D">D.D. Zhang</name></author><author><name sortKey="Wang, C Q" uniqKey="Wang C">C.Q. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C R" uniqKey="Wang C">C.R. Wang</name></author><author><name sortKey="Wang, X J" uniqKey="Wang X">X.J. Wang</name></author><author><name sortKey="Su, Z J" uniqKey="Su Z">Z.J. Su</name></author><author><name sortKey="Fei, H J" uniqKey="Fei H">H.J. Fei</name></author><author><name sortKey="Liu, X Y" uniqKey="Liu X">X.Y. Liu</name></author><author><name sortKey="Pan, Q X" uniqKey="Pan Q">Q.X. Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gauthier, C" uniqKey="Gauthier C">C. Gauthier</name></author><author><name sortKey="Legault, J" uniqKey="Legault J">J. Legault</name></author><author><name sortKey="Girard Lalancette, K" uniqKey="Girard Lalancette K">K. Girard-Lalancette</name></author><author><name sortKey="Mshvildadze, V" uniqKey="Mshvildadze V">V. Mshvildadze</name></author><author><name sortKey="Pichette, A" uniqKey="Pichette A">A. Pichette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilabert Oriol, R" uniqKey="Gilabert Oriol R">R. Gilabert-Oriol</name></author><author><name sortKey="Mergel, K" uniqKey="Mergel K">K. Mergel</name></author><author><name sortKey="Thakur, M" uniqKey="Thakur M">M. Thakur</name></author><author><name sortKey="Von Mallinckrodt, B" uniqKey="Von Mallinckrodt B">B. von Mallinckrodt</name></author><author><name sortKey="Melzig, M F" uniqKey="Melzig M">M.F. Melzig</name></author><author><name sortKey="Fuchs, H" uniqKey="Fuchs H">H. Fuchs</name></author><author><name sortKey="Weng, A" uniqKey="Weng A">A. Weng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Yang, N D" uniqKey="Yang N">N.D. Yang</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F. Zhou</name></author><author><name sortKey="Shen, T" uniqKey="Shen T">T. Shen</name></author><author><name sortKey="Duan, T" uniqKey="Duan T">T. Duan</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y. Shi</name></author><author><name sortKey="Zhu, X Q" uniqKey="Zhu X">X.Q. Zhu</name></author><author><name sortKey="Shen, H M" uniqKey="Shen H">H.M. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broker, L E" uniqKey="Broker L">L.E. Broker</name></author><author><name sortKey="Huisman, C" uniqKey="Huisman C">C. Huisman</name></author><author><name sortKey="Span, S W" uniqKey="Span S">S.W. Span</name></author><author><name sortKey="Rodriguez, J A" uniqKey="Rodriguez J">J.A. Rodriguez</name></author><author><name sortKey="Kruyt, F A E" uniqKey="Kruyt F">F.A.E. Kruyt</name></author><author><name sortKey="Giaccone, G" uniqKey="Giaccone G">G. Giaccone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michallet, M C" uniqKey="Michallet M">M.C. Michallet</name></author><author><name sortKey="Saltel, F" uniqKey="Saltel F">F. Saltel</name></author><author><name sortKey="Flacher, M" uniqKey="Flacher M">M. Flacher</name></author><author><name sortKey="Revillard, J P" uniqKey="Revillard J">J.P. Revillard</name></author><author><name sortKey="Genestier, L" uniqKey="Genestier L">L. Genestier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tait, S W G" uniqKey="Tait S">S.W.G. Tait</name></author><author><name sortKey="Ichim, G" uniqKey="Ichim G">G. Ichim</name></author><author><name sortKey="Green, D R" uniqKey="Green D">D.R. Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name></author><author><name sortKey="Antunes, F" uniqKey="Antunes F">F. Antunes</name></author><author><name sortKey="Eaton, J W" uniqKey="Eaton J">J.W. Eaton</name></author><author><name sortKey="Brunk, U T" uniqKey="Brunk U">U.T. Brunk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diebold, L" uniqKey="Diebold L">L. Diebold</name></author><author><name sortKey="Chandel, N S" uniqKey="Chandel N">N.S. Chandel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanzawa, T" uniqKey="Kanzawa T">T. Kanzawa</name></author><author><name sortKey="Germano, I M" uniqKey="Germano I">I.M. Germano</name></author><author><name sortKey="Komata, T" uniqKey="Komata T">T. Komata</name></author><author><name sortKey="Ito, H" uniqKey="Ito H">H. Ito</name></author><author><name sortKey="Kondo, Y" uniqKey="Kondo Y">Y. Kondo</name></author><author><name sortKey="Kondo, S" uniqKey="Kondo S">S. Kondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Duan, H" uniqKey="Duan H">H. Duan</name></author><author><name sortKey="Tong, X" uniqKey="Tong X">X. Tong</name></author><author><name sortKey="Hsu, P" uniqKey="Hsu P">P. Hsu</name></author><author><name sortKey="Han, L" uniqKey="Han L">L. Han</name></author><author><name sortKey="Morris Natschke, S L" uniqKey="Morris Natschke S">S.L. Morris-Natschke</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Lee, K H" uniqKey="Lee K">K.H. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khinkis, L A" uniqKey="Khinkis L">L.A. Khinkis</name></author><author><name sortKey="Levasseur, L" uniqKey="Levasseur L">L. Levasseur</name></author><author><name sortKey="Faessel, H" uniqKey="Faessel H">H. Faessel</name></author><author><name sortKey="Greco, W R" uniqKey="Greco W">W.R. Greco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierzynska Mach, A" uniqKey="Pierzynska Mach A">A. Pierzynska-Mach</name></author><author><name sortKey="Janowski, P A" uniqKey="Janowski P">P.A. Janowski</name></author><author><name sortKey="Dobrucki, J W" uniqKey="Dobrucki J">J.W. Dobrucki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salvioli, S" uniqKey="Salvioli S">S. Salvioli</name></author><author><name sortKey="Ardizzoni, A" uniqKey="Ardizzoni A">A. Ardizzoni</name></author><author><name sortKey="Franceschi, C" uniqKey="Franceschi C">C. Franceschi</name></author><author><name sortKey="Cossarizza, A" uniqKey="Cossarizza A">A. Cossarizza</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Hong, Jun Man" sort="Hong, Jun Man" uniqKey="Hong J" first="Jun-Man" last="Hong">Jun-Man Hong</name><name sortKey="Hwang, Young Il" sort="Hwang, Young Il" uniqKey="Hwang Y" first="Young-Il" last="Hwang">Young-Il Hwang</name><name sortKey="Lee, Wang Jae" sort="Lee, Wang Jae" uniqKey="Lee W" first="Wang Jae" last="Lee">Wang Jae Lee</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin-Hee" last="Kim">Jin-Hee Kim</name></noRegion><name sortKey="Kim, Hyemin" sort="Kim, Hyemin" uniqKey="Kim H" first="Hyemin" last="Kim">Hyemin Kim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000448 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000448 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6766801
|texte= SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31491945" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |